PROLINE vs. PROLINE Plus: What’s the Real Difference?

If you have seen both PROLINE and PROLINE Plus in lab equipment catalogs, you might wonder if the Plus version is a real upgrade. The PROLINE Plus is the newer and better version of the original PROLINE mechanical pipette from Sartorius. It has better ergonomics, advanced features, and a modern design that makes pipetting easier and more accurate.

The PROLINE Plus pipette is built for comfort and performance. It uses low pipetting forces, has a comfortable handle, and includes an ergonomic finger support that reduces hand strain during long lab sessions. This design helps you grip the pipette better and minimizes fatigue, which is especially important if you pipette hundreds of times per day in research or routine testing work.

One big improvement in PROLINE Plus is the click-stop volume adjustment system. With this feature, you can set the volume quickly and precisely without guessing. The large forward-facing volume display also makes it easy to read the settings from any angle. For example, if you need to switch between 50 µL and 100 µL during an experiment, the click-stop lets you do it in seconds without fumbling with old dials.

The PROLINE Plus multichannel pipette has Optiload spring-loaded tip cones. This means you can load and eject tips with much less force than the original PROLINE. In practice, this reduces the risk of hand injuries when working with 8-channel or 12-channel pipettes. For instance, a lab technician using a 10–100 µL multichannel PROLINE Plus can load all 12 tips in one smooth motion, while the original PROLINE might require more finger pressure and multiple attempts.

PROLINE Plus also protects your samples better. For models above 10 µL, it includes a replaceable Safe-Cone Filter inside the tip-cone. This filter stops liquids from entering the pipette body, which prevents contamination of both your samples and the instrument. If you work with hazardous chemicals or sensitive biological samples, this feature helps keep your work area clean and safe.

Cleaning and maintenance are simpler with PROLINE Plus because it is fully autoclavable without taking it apart. You can sterilize the entire pipette at 121°C for 20 minutes, which is standard in many labs. The original PROLINE often requires partial disassembly before autoclaving, adding extra steps. With PROLINE Plus, you only need to separate 3 parts for deep cleaning, saving time and reducing the chance of losing small components.

The PROLINE Plus is made with materials that resist chemicals and UV light better than the original. This means the pipette lasts longer even in harsh lab environments with frequent exposure to solvents or UV sterilization cabinets. For example, a PROLINE Plus used daily in a PCR lab with UV decontamination will show less wear and cracking over time compared to an older PROLINE model.

PROLINE Plus covers a wide range of volumes. Single-channel models work from 0.1 µL up to 10,000 µL, with fixed-volume options at 5 µL, 10 µL, 25 µL, 50 µL, 100 µL, 200 µL, 1,000 µL, and 10,000 µL. Multichannel versions cover 0.5 µL to 300 µL. This flexibility lets you use one PROLINE Plus pipette for DNA quantification at 0.5 µL and buffer preparation at 5,000 µL, while the original PROLINE may have fewer fixed-volume choices.

If you do basic pipetting occasionally, the original PROLINE might still work for your needs. But if you pipette daily, handle many samples, or want better comfort and accuracy, PROLINE Plus is the clear upgrade. Labs that switched to PROLINE Plus report fewer hand complaints, faster volume changes, and longer instrument life. For most modern labs, the PROLINE Plus is the standard choice for mechanical pipetting today.

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